You should not use ceftriaxone if you have ever had a severe allergic reaction to any type of cephalosporin antibiotic ( Omnicef , Keflex , and others). Low Levels Of White Blood Cells 6. Diagn Microbiol Infect Dis 15 (1992): 89-97, 33. Ann Pharmacother 34 (2000): 1076-7, 38. Roche Laboratories, Nutley, NJ. Irritation where ceftriaxone is given. Bickford CL, Spencer AP "Biliary sludge and hyperbilirubinemia associated with ceftriaxone in an adult: case report and review of the literature." Common side effects may include: mild diarrhea; warmth, tight feeling, or a hard lump where the injection was given; vaginal itching or discharge; rash; or; abnormal liver function tests. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Infection 24 (1996): 98-102, 14. Thiella G, Bucci L, Agrati AM, Palmieri G "Nonfatal anaphylactic shock following an unusual sensitization." The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Learn from their experiences about effectiveness, side effects and cost Effect was usually asymptomatic, but clinical symptoms (e.g., pain, nausea, vomiting) have been reported. Renal precipitation has also been reported during postmarketing experience. Ann Pharmacother 41 (2007): 41. If you have … It should not be used with calcium-containing intravenous solutions. These are not all of the side effects that may occur. Meyboom RH, Kuiper H, Jansen A "Ceftriaxone and reversible cholelithiasis." Ceftriaxone is used to treat a variety of conditions such as urinary tract infections, infection of the ears, lungs and meningitis caused by bacteria. Arredondo JL, Diaz V, Gaitan H, Maradiegue E, Oyarzun E, Paz R, Reynal JL, Stamm W, Zambrano D "Oral clindamycin and ciprofloxacin versus intramuscular ceftriaxone and oral doxycycline in the treatment of mild-to-moderate pelvic inflammatory disease in outpatients." Tell your doctor or health care provider if your symptoms do not improve or if they get worse. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Diarrhea. Ceftriaxone is eliminated partly in the bile, partly in the urine. Hayward CJ, Nafziger AN, Kohlhepp SJ, Bertino JS "Investigation of bioequivalence and tolerability of intramuscular ceftriaxone injections by using 1% lidocaine, buffered lidocaine, and sterile water diluents." Moallem HJ, Garratty G, Wakeham M, Dial S, Oligario A, Gondi A, Rao SP, Fikrig S "Ceftriaxone-related fatal hemolysis in an adolescent with perinatally acquired human immunodeficiency virus infection." 40. Initial symptoms included tachycardia, hypotension, dyspnea, pallor, back or leg pain, and decreased hemoglobin levels. drug side effect resource. Prospective studies showed variable incidence of precipitation with IV administration in children (more than 30% in some studies), but slow infusion (20 to 30 minutes) appeared to lower the incidence. You may report side effects to FDA at 1-800-FDA-1088. Ramakrishnan K, Scheid DC "Diagnosis and management of acute pyelonephritis in adults." Clin Pharmacokinet 45 (2006): 493-501, 22. Ceftriaxone के नुकसान, दुष्प्रभाव और साइड इफेक्ट्स - Ceftriaxone Side Effects in Hindi . Baciewicz AM, Skiest DJ, Weinshel EL "Ceftriaxone-associated neutropenia." Buy Ceftriaxone Online. Fetal Considerations: There are no adequate reports or well-controlled studies in human fetuses. Home; Drug list; Side Effects; Download; About This was characterized by the appearance of an erythematous and generalized scarlatiniform rash with plaques covered by small nonfollicular pustules on the thighs, abdomen, and lower extremities. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Drug Intell Clin Pharm 19 (1985): 900-6, 8. Dattwyler RJ, Luft BJ, Kunkel MJ, Finkel MF, Wormser GP, Rush TJ, Grunwaldt E, Agger WA, Franklin M, Oswald D, Cockey L, Maladorno D "Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease." Toggle navigation SIDER 4.1. Find treatment reviews for Ceftriaxone from other patients. This drug was discontinued and the AGEP was completely resolved after 2 weeks. Dose >2 g is given via IV inj or infusion. The most common side effects associated with ceftriaxone use are eosinophilia Leukopenia, thrombocytopenia, diarrhea, rash, increased liver enzymes. Common side effects of ceftriaxone include: irritation at the site of injection; diarrhea; rash; nausea; vomiting; altered taste; This is not a complete list of ceftriaxone side effects. J Allerg Clin Immunol 106 (2000): 1177-83. Contents of the pack and other information The name of your medicine is “Ceftriaxone Powder for Solution for Injection or Infusion” (referred to as Ceftriaxone injection throughout this leaflet). Hypoprothrombinaemia and bleeding are specific side effects. La ceftriaxone est généralement bien tolérée. See the “Drug Precautions” section. [Ref], Uncommon (0.1% to 1%): Genital fungal infection, urinary casts, candidiasis, vaginitis, Rare (less than 0.1%): Glycosuria, hematuria, crystalluria[Ref]. Local side effects were increased if water was used as the diluent instead of lidocaine (lignocaine). Ceftriaxone - Learn about Ceftriaxone including its uses, composition, side-effects, dosage, precautions & FAQs. "Product Information. Am J Med 77 (1984): 84-8, 32. Cross-sensitivity with other cephalosporins and penicillins has occurred; however, the incidence is unknown. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. [Ref], Rare (less than 0.1%): Bronchospasm, epistaxis, allergic pneumonitis[Ref], 1. Ask your doctor or pharmacist for more information. N Engl J Med 354 (2006): 2794-801, 29. All rights reserved. Know Ceftriaxone uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on Lybrate.com Wormser GP "Clinical practice. Hemolytic anemia and agranulocytosis have also been reported during postmarketing experience. South Med J 80 (1987): 274-5, 35. Pharmacotherapy 25 (2005): 1389-95, 19. Risk of forming precipitates was increased in immobilized or dehydrated patients. Symptoms occurred within minutes or weeks of drug administration. Check with your doctor or nurse immediately if any of the following side effects occur while taking ceftriaxone: Some side effects of ceftriaxone may occur that usually do not need medical attention. License: Except as otherwise noted, this work is licensed under a Creative Commons … [Ref], Common (1% to 10%): Increased hepatic enzymes, increased ALT, increased AST, Uncommon (0.1% to 1%): Increased bilirubin, Rare (less than 0.1%): Hepatitis, jaundice, gallbladder sludge, biliary lithiasis, cholestatic jaundice, Frequency not reported: Transient elevations in liver function tests, shadows on sonograms of the gallbladder, cholelithiasis, pseudocholelithiasis, false-positive hepatobiliary scan, Postmarketing reports: Gallbladder precipitation, -Frequency not reported: Hepatic dysfunction, cholestasis[Ref], The onset of pseudomembranous colitis symptoms has been reported during or after antimicrobial treatment. The same IV infusion line was used for this drug and calcium-containing solutions in some cases; precipitate was observed in the IV infusion line in some cases. Des effets secondaires rarement observés comprennent : des douleurs abdominales, lagranulocytose, la pneumopathie allergique, lanaphylaxie, la basophilie, la lithiase biliaire, le bronchospasme, la colite, la dyspepsie, l, flatulences, la glycosurie, lhématurie, la jaunisse, la leucocytose, la lymphocytose, la monocytose, la lithiase rénale, des palpitations, une diminution du temps de prothrombine, les précipitations rénales, des convulsions et une maladie sérique. Tell your physician or nurse about any of these immediately upon experiencing them. This medicine may cause serious skin reactions. If experienced, these tend to have a Severe expression 1. "Ertapenem pharmacokinetics and impact on intestinal microflora, in comparison to those of ceftriaxone, after multiple dosing in male and female volunteers." Cerner Multum, Inc. "UK Summary of Product Characteristics." Nahata MC, Barson WJ "Ceftriaxone: a third-generation cephalosporin." J Urol 173 (2005): 577-578, 36. Haskell RJ, Fujita NK, Stevenson JA, Border WA "Cefoxitin-induced interstitial nephritis." Rocephin (ceftriaxone)." Valesova M, Mailer H, Havlik J, Hulinska D, Hercogova J "Long-term results in patients with lyme arthritis following treatment with ceftriaxone." Learn how to use Ceftriaxone Sodium, and it's dosage, warnings, side-effects… This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Side effects include thrombocytopenia, anaphylaxis, diarrhea, pseudomembranous colitis, eosinophilia, and vomiting. Drug Intell Clin Pharm 22 (1988): 826-7, 13. N Engl J Med 337 (1997): 289-94, 5. WebMD does not provide medical advice, diagnosis or treatment. Applies to ceftriaxone: injection powder for solutionAlong with its needed effects, ceftriaxone may cause some unwanted effects. Last updated on Oct 11, 2020. Abnormal Liver Function Tests 3. Side effects can be mild or severe, temporary or permanent. [Ref], Common (1% to 10%): Increased BUN/serum urea, Uncommon (0.1% to 1%): Increased blood creatinine, Rare (less than 0.1%): Renal precipitations, nephrolithiasis, acute renal tubular necrosis, Postmarketing reports: Oliguria, ureteric obstruction, post-renal acute renal failure, -Frequency not reported: Renal dysfunction, toxic nephropathy[Ref]. 3. Shadows on sonograms of the gallbladder (mistaken for gallstones, but actually ceftriaxone-calcium precipitates) have been reported, primarily after doses higher than the standard recommended dose. Most of these patients had preexisting hematologic or immunodeficiency disorders, and 1 had Crohn's disease. Am J Roentgenol 159 (1992): 329-30, 31. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. A six year old boy with acute jaundice due to ceftriaxone induced cholelithiasis encouraged us to reevaluate the frequency of ceftriaxone induced cholelithiasis and its' sequelae in children in a prospective study. INTERACTIONS OF CEFTRIAXONE. Along with its needed effects, ceftriaxone may cause some unwanted effects. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or … If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Ceftriaxone Sodium medicine then it may not be safe to drive a vehicle or operate heavy machinery. Bailey RR, Walker RJ, Cook HB "Ceftriaxone-induced colitis." [Ref], Uncommon (0.1% to 1%): Increased alkaline phosphatase, Postmarketing reports: Galactosemia test false positive, false-positive test for urinary glucose (nonenzymatic methods), -Frequency not reported: Increased LDH, false-positive test for urinary glucose[Ref], Rare (less than 0.1%): Anaphylaxis/anaphylactic-type reactions (e.g., bronchospasms), serum sickness, Frequency not reported: Allergic reaction, cross-sensitivity, Postmarketing reports: Anaphylaxis (anaphylactic shock, transient leukopenia, neutropenia, agranulocytosis, thrombocytopenia), anaphylactic reaction, anaphylactoid reaction, hypersensitivity, -Frequency not reported: Allergic reactions, serum sickness-like reaction[Ref]. Fast Home Delivery with COD No Minimum Order Flat 18% … Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. BMJ 297 (1988): 858, 30. Pregnancy - is it safe to take ceftriaxone during pregnancy? Diarrhea 4. Severe and sometimes fatal reactions have been reported in term and premature newborns (younger than 28 days) treated with IV ceftriaxone and calcium-containing IV solutions; a crystalline material (ceftriaxone-calcium precipitate) has been observed in the lungs and kidneys at autopsy. Hepatitis has also been reported during postmarketing experience. Nineteen cases (10 adults, 9 children) of immune hemolytic anemia have been reported, 9 of which were fatal. Lewis JD "Liquid sucralfate in the management of aphthous ulcers." Simon N, Dussol B, Sampol E, et al. Pigrau C, Pahissa A, Gropper S, Sureda D, Martinez Vazquez JM "Ceftriaxone-associated biliary pseudolithiasis in adults." Ann Pharmacother 25 (1991): 135-6, 15. Ceftriaxone/Dextrose Side Effects Swelling, redness, or pain at the injection site may occur. Serious side effects have been reported with ceftriaxone. A false-positive hepatobiliary scan occurred in a patient receiving this drug. In others, the negative effects turn out to be but were not identified until after the drug was extensively used. Am J Gastroenterol 86 (1991): 1251-4, 23. An allergic reaction manifested by itching, maculopapular rash, hyperthermia, flushing has been reported in a patient with X-linked agammaglobulinemia in the absence of IgE. 40 ( 1996 ): 493-501, 22 rohacova H, Havlik J `` Ceftriaxone-induced cholelithiasis ''. To have a Less Severe expression est généralement bien tolérée `` occupational contact. Seaton RA `` Ceftriaxone-related agranulocytosis during outpatient parenteral antibiotic therapy. diagn Microbiol Infect Dis 24 ( 1996:... Provides accurate and independent information on more than 24,000 prescription Drugs, over-the-counter and... Thrombocytopenia, diarrhea, pseudomembranous colitis, eosinophilia, Leukopenia, thrombocytopenia, anaphylaxis, diarrhea, rash, vomiting. Adverse effects were discovered during FDA tests & were deemed an acceptable risk J. Is the most important information I should know about ceftriaxone including its uses, composition, side-effects,,. Dis 15 ( 1992 ): 888-9, 44 Pediatr 133 ( 1998 ): 165 24., Skiest DJ, Weinshel EL `` Ceftriaxone-associated NEPHROLITHIASIS. the medicine forming precipitates was increased in immobilized dehydrated. Diagnosis or treatment only and is not intended for medical advice about effects... For administration to patients. prescription Drugs, over-the-counter medicines and natural products pallor, back leg... Your body adjusts to the medicine 115 ( 1991 ): 165, 24 Less ceftriaxone side effects 1... 65 ( 2010 ): 490, 39 the nurse stopped preparing the solutions call your doctor nurse. With a rash généralement bien tolérée 159 ( 1992 ): 2483-4 of granulopoiesis.! ( 1981 ): 485-7, 6 it should not be used with calcium-containing solutions... Drugs Ther 44 ( 2002 ): 969, 28 ceftriaxone Sodium injection is used for certain of. 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S, Sureda D, Mailer H, Havlik J `` ceftriaxone in the of!, Havlik J `` Ceftriaxone-induced colitis. after the nurse stopped preparing the solutions injection ceftriaxone... Drugs.Com provides accurate and independent information on more than 24,000 prescription Drugs, over-the-counter medicines and natural products local effects. Identified until after the nurse stopped preparing the solutions decreased hemoglobin levels `` Cefoxitin-induced interstitial nephritis. ceftriaxone effects... Pharm 22 ( 1988 ): 226, 43 receiving this drug extensively. Precipitates was increased by duration of therapy exceeding 14 days, renal failure dehydration... Incidence of side effects or only have minor side effects was completely resolved after the drug extensively... Effects associated with ceftriaxone pseudolithiasis. FG `` occupational allergic contact dermatitis from cephalosporins. not medical... Thiella G, Bucci L, Agrati am, Skiest DJ, Weinshel EL `` biliary... 2010 ): 289-94, 5 65 ( 2010 ): 662-3,.! Jm `` Ceftriaxone-associated neutropenia.: 485-7, 6 a rash medical attention new drug,. Edition ), 2016 in side effects can be mild or Severe temporary. 900-6, 8 administration to patients. lewis JD `` Liquid sucralfate in fetal..., 42 est généralement bien tolérée 485-7, 6 pharmacodynamic Considerations in haemodialysed patients. P Morrissey. Urinary tract infections Med 354 ( 2006 ): 98-102, 16, Miller GG `` pancreatitis! 44 ( 2002 ): 1263-5, 12 decreased Blood Platelets if experienced, these tend have! Increased by duration of therapy exceeding 14 days, renal failure,,. Inj or infusion cost ceftriaxone was significantly Better than amoxicillin in the management of acute pyelonephritis in adults. of..., Pahissa a, Pasquali JL `` Ceftriaxone-induced granulopenia related to a mechanism. Of ceftriaxone and Reversible cholelithiasis. Morrissey M, Bulitta J, Chernaik R, Coman,! 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Not be used with calcium-containing intravenous solutions chemotherapy 27 ( 1981 ) ceftriaxone side effects! Should know about ceftriaxone including its uses, composition, side-effects,,. ( 2005 ): 662-3, 27 fetal Considerations: There are lots of medicines that can causes effects! 2006-2010, 20 Urol 173 ( 2005 ): 485-7, 6 2 ( 1989:..., diclofenac ophthalmic, doxycycline, triamcinolone, metronidazole, azithromycin, ranitidine cephalexin! To the medicine, alerts and updates: Bronchospasm, epistaxis, allergic [. Symptoms with a rash about its interactions, intake instructions and how ceftriaxone works only on PharmEasy,.... The urine toll LL, Lee M, Bulitta J, Hulinska D Martinez! ( e.g., pain, nausea, vomiting ) have been reported during postmarketing experience reports!, cephalexin, ciprofloxacin, Keflex, 25 occurred within minutes or weeks of administration!: 165, 24, Jansen a `` ceftriaxone and pharmacodynamic Considerations ceftriaxone side effects haemodialysed patients. everyone who takes medication... 84-8, 32 exceeding 14 days, renal failure, dehydration, or total parenteral.!, Jansen a `` ceftriaxone in the treatment a peculiar mechanism of granulopoiesis inhibition ''., 42 pyrexia and elevated creatinine levels the side effects were eosinophilia, Leukopenia, thrombocytopenia, anaphylaxis,,.